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Produções Científicas

07 de abril 2021

Validation of the Adolescent Barriers Questionnaire for use in Brazilian adolescents with cancer

Objective: To translate, culturally adapt, and evaluate the psychometric properties of Adolescent Barriers Questionnaire for use in Brazilian adolescents with cancer aged 12 to 18 years, based on the original American Adolescent Barriers Questionnaire which was designed to measure the extent to which adolescents with cancer have concerns about reporting pain and using analgesics. Methods: The study analyzed the psychometric properties reliability (internal consistency and test-retest) and validity (known groups and convergent) of Adolescent Barriers Questionnaire in adolescents between 12...

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07 de abril 2021

Vaginal sparing in laparoscopic radical cystectomy for females: feasibility and technical notes

Anterior pelvic exenteration with urinary diversion (UD) and extended lymphadenectomy is the standard procedure for invasive tumors of the bladder in women (1), resulting in 52% of female sexual dysfunction after the procedure (2). Less radical techniques with pelvic organ preservation are viable alternatives in selected cases such as sexually active women with early-stage neoplasms (3). Although still with preliminary data, these techniques seem to respect the foundations of the TRIFECTA principle (2). The objective of this video is demonstrate...

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07 de abril 2021

Using Co-segregation and Loss of Heterozygosity Analysis to Define the Pathogenicity of Unclassified Variants in Hereditary Breast Cancer Patients

The use of gene panels introduces a new dilemma in the genetics field due to the high frequency of variants of uncertain significance (VUS). The objective of this study was to provide evidence that may help in the classification of these germline variants in terms of their clinical impact and association with the disease in question. A total of 52 unrelated women at-risk for HBOC and negative for BRCA1/BRCA2 pathogenic variants were evaluated through a gene panel comprising 14 breast...

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07 de abril 2021

Universal cervical cancer control through a right to health lens: refocusing national policy and programmes on underserved women

Background: Cervical cancer claims 311,000 lives annually, and 90% of these deaths occur in low- and middleincome countries. Cervical cancer is a highly preventable and treatable disease, if detected through screening at an early stage. Governments have a responsibility to screen women for precancerous cervical lesions. Yet, national screening programmes overlook many poor women and those marginalised in society. Under-screened women (called hard-to-reach) experience a higher incidence of cervical cancer and elevated mortality rates compared to regularly-screened women. Such inequalities...

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07 de abril 2021

The Role of Fusobacterium nucleatum in Colorectal Carcinogenesis

Colorectal cancer (CRC) is one of the most frequent and deadly neoplasms worldwide. Genetic factors, lifestyle habits, and inflammation are important risk factors associated with CRC development. In recent years, growing evidence has supporting the significant role of the intestinal microbiome in CRC carcinogenesis. Disturbances in the healthy microbial balance, known as dysbiosis, are frequently observed in these patients. Pathogenic microorganisms that induce intestinal dysbiosis have become an important target to determine the role of bacterial infection in tumorigenesis. Interestingly,...

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