Grupos de Pesquisas
Imuno-Oncologia
O grupo de pesquisa em Imuno-Oncologia surgiu em 2019-2020 com o objetivo de estudar o papel da resposta imune dos pacientes com câncer, quando tratados com imunoterapia. O objetivo principal desta tinha de pesquisa é investigar marcadores imunológicos capazes de distinguir pacientes respondedores de não-respondedores à terapia com inibidores de checkpoint imunológico, em pacientes tratados no Hospital de Amor de Barretos. Acreditamos que com a caracterização do sistema imune destes pacientes, possamos guiar a expansão da imunoterapia para nossa população e assim, poderemos desenvolver melhores estratégias para a identificação dos pacientes que se beneficiarão deste tratamento, permitindo o uso racional desta abordagem terapêutica. Esperamos que os resultados obtidos possam ser aplicados na prática clínica da especialidade, permitindo um melhor delineamento do prognóstico, além do desenvolvimento de novos esquemas terapêuticos para o tratamento destes pacientes, de forma a contribuir para melhoras nas taxas de sobrevida e na qualidade de vida.
Membros de Equipe
Pesquisador Principal
Lidia Maria Rebolho Batista Arantes – PhD
http://lattes.cnpq.br/2019308149950531 lirebolho@hotmail.com
Pesquisadores Colaboradores
Alunos
Airam Barbosa De Moura
Bolsista de Apoio Técnico DTI-A CNPq
http://lattes.cnpq.br/7204215619360305 airambarbosa31@hotmail.com
Amanda Miranda Martins
Aluna de Iniciação Científica
http://lattes.cnpq.br/0612313214657250 am.martins@unesp.br
Angelina Crepaldi Camargo Lima
Aluna de Iniciação Científica
https://lattes.cnpq.br/2533174111536462 angelinaccl22@gmail.com
Bruna Pereira Sorroche
Aluna de Pós-Doutorado
http://lattes.cnpq.br/6362727361627859 brusorroshe@hotmail.com
Bruno de Oliveira Fonseca
Aluno de Doutorado
http://lattes.cnpq.br/3579871105794318 bolfonseca1@gmail.com
Isabela Cristiane Tosi
Aluna de Mestrado
http://lattes.cnpq.br/1817922254096303 isabelatosi14@gmail.com
Joyce Alessandra Lima
Aluna de Mestrado
http://lattes.cnpq.br/7686481062860307 joycealima@yahoo.com.br
Katiane Tostes
Aluna de Doutorado Direto
http://lattes.cnpq.br/6908270119532210 katianetostes@hotmail.com
Nathália de Carvalho Rodrigues
Aluna de Mestrado
http://lattes.cnpq.br/8977011113761985 nathaliadecr@gmail.com
Renan de Jesus Teixeira
Aluno de Doutorado
http://lattes.cnpq.br/6731586162750786 renandjt98@gmail.com
Tauana Christina Dias
Aluna de Doutorado
http://lattes.cnpq.br/1899842589164857 tauanac.dias@gmail.com
Victor Gabriel Paes
Aluno de Mestrado
http://lattes.cnpq.br/8286613750799076 victorgpaes23@gmail.com
Vinícius Gonçalves de Souza
Aluno de Doutorado Direto
http://lattes.cnpq.br/8476923473163421 vinicius.gs2110@gmail.comAlunos Egressos
Publicações Relevantes
HOXA1 3’UTR methylation as prognostic biomarker in oral squamous cell carcinoma
SORROCHE, B. P. ; MIRANDA, K. C. ; MORAES, C. B. ; ARANTES LMRB ; KOWALSKI, L. P. ; MARCHI, F. A. ; ROGATTO, S. R. ; ALMEIDA, J. D. . Cancers, v. 16, p. 874, 2024.
Immune-checkpoint gene expression and BCG response in non-muscle invasive bladder cancer
ZUCCA, L. E. ; LAUS, A. C. ; SORROCHE, B. P. ; PARO, E. ; SUSSUCHI, L. ; MARQUES, R. F. ; BERARDINELLI, G. N. ; TEIXEIRA, G. R. ; Arantes LMRB ; REIS, R. M. ; CARCANO, F. M. Translational Oncology, 2024.
Immunohistochemistry assessment of tissue neutrophil-to-lymphocyte ratio (tNLR) predicts outcomes in melanoma patients treated with anti-programmed cell death 1 therapy.
TEIXEIRA, R. J. ; SOUZA, V. G. ; SORROCHE, B. P. ; PAES, V. G. ; ZAMBUZI-ROBERTO, F. A. ; PEREIRA, C. A. D. ; VAZQUEZ, V. L. ; Arantes LMRB . MELANOMA RESEARCH, v. 16, p. 1, 2024.
The Mutographs biorepository: A unique genomic resource to study cancer around the world.
PERDOMO, SANDRA ; ABEDI-ARDEKANI, BEHNOUSH ; DE CARVALHO, ANA CAROLINA ; FERREIRO-IGLESIAS, AIDA ; GABORIEAU, VALÉRIE ; CATTIAUX, THOMAS ; RENARD, HÉLÈNE ; CHOPARD, PRISCILIA ; CARREIRA, CHRISTINE ; SPANU, ANDREEA ; NIKMANESH, ARASH ; CARDOSO PENHA, RICARDO CORTEZ ; ANTWI, SAMUEL O. ; ASHTON-PROLLA, PATRICIA ; CANOVA, CRISTINA ; CHITAPANARUX, TANED ; COX, RILEY ; CURADO, MARIA PAULA ; DE OLIVEIRA, JOSÉ CARLOS ; ARANTES LMRB . Cell Genomics, v. 1, p. 100500, 2024.
PD-L1 tumor expression as a predictive biomarker of immune checkpoint inhibitors response and survival in advanced melanoma patients in Brazil. Diagnostics
miR -99a-5p as a biomarker for lymph node metastasis prediction in oral squamous cell carcinoma patients
COUSSEAU, CRISTIANE PEREIRA VARGAS ; SORROCHE, BRUNA PEREIRA ; DE JESUS TEIXEIRA, RENAN ; DE CARVALHO, ANA CAROLINA ; MELENDEZ, MATIAS ELISEO ; DE CASTRO CAPUZZO, RENATO ; LAUS, ANA CAROLINA ; DA SILVA, LUCIANE SUSSUCHI ; DE MENEZES, NEI SOARES ; CARVALHO, ANDRÉ LOPES ; ARANTES, LIDIA MARIA REBOLHO BATISTA . HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, v. Jul 31, p. 1-9, 2023.
Biomarkers for Immune Checkpoint Inhibitor Response in NSCLC: Current Developments and Applicability.
TOSTES, KATIANE ; SIQUEIRA, ALÉXIA POLO ; REIS, RUI MANUEL ; LEAL, LETICIA FERRO ; ARANTES, LIDIA MARIA REBOLHO BATISTA . INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 24, p. 11887, 2023.
Unveiling the role of MGMT and DAPK hypermethylation in response to anti-EGFR agents: molecular insights for advancing HNSCC treatment.
Arantes LMRB; SILVA-OLIVEIRA, R. J. ; CARVALHO, A. C. ; MELENDEZ, M. E. ; SORROCHE, B. P. ; TEIXEIRA, R. J. ; TOSTES, K. ; PALMERO, E. I. ; REIS, R. M. ; Carvalho, AL . HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, v. 12, p. 1, 2023.
Using machine learning and an electronic tongue for discriminating saliva samples from oral cavity cancer patients and healthy individuals
BRAZ, D. C. ; POPPOLIN-NETO, M. ; SHIMIZU, F. M. ; SA, A. C. ; MELENDEZ, M. E. ; Arantes LMRB ; Carvalho, AL ; REIS, R. M. ; PAULOVICH, F. V. ; OLIVEIRA, OSVALDO NOVAIS . Using machine learning and an electronic tongue for discriminating saliva samples from oral cavity cancer patients and healthy individuals. TALANTA, v. 243, p. 123327, 2022.
Co-expression of TNF receptors 1 and 2 on melanomas facilitates soluble TNF-induced resistance to MAPK pathway inhibitors. Journal of Translational Medicine
SANDER, CINDY A. ; RUSH, ELIZABETH A. ; SHI, JIAN ; ARANTES, LIDIA M. R. B. ; TESI, RAYMOND J. ; ROSS, MARK A. ; CALDERON, MICHAEL J. ; WATKINS, SIMON C. ; KIRKWOOD, JOHN M. ; FERRIS, ROBERT L. ; BUTTERFIELD, LISA H. ; VUJANOVIC, LAZAR . Co-expression of TNF receptors 1 and 2 on melanomas facilitates soluble TNF-induced resistance to MAPK pathway inhibitors. Journal of Translational Medicine, v. 20, p. 331, 2022.
Analysis of Epstein-Barr Virus (EBV) and PD-L1 Expression in Nasopharyngeal Carcinoma Patients in a Non-Endemic Region. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
DIAS, JOSIANE M. ; SANTANA, IARA V. V. ; DA SILVA, VINICIUS D. ; CARVALHO, ANDRÉ L. ; ARANTES, LIDIA M. R. B. . Analysis of Epstein-Barr Virus (EBV) and PD-L1 Expression in Nasopharyngeal Carcinoma Patients in a Non-Endemic Region. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 23, p. 11720, 2022.
DNA Methylation Markers from Negative Surgical Margins Can Predict Recurrence of Oral Squamous Cell Carcinoma. Cancers
SORROCHE, B. P. ; TALUKDAR, F. R. ; LIMA, S. C. S. ; MELENDEZ, M. E. ; CARVALHO, A. C. ; ALMEIDA, G. C. ; MARCHI, P. R. M. ; LOPES, M. ; PINTO, L. F. R. ; Carvalho, AL ; HERCEG, Z. ; Arantes LMRB . DNA Methylation Markers from Negative Surgical Margins Can Predict Recurrence of Oral Squamous Cell Carcinoma. Cancers, v. 13, p. 2915, 2021.
Evaluation of acetylation and methylation in oral rinse of patients with head and neck cancer history exposed to valproic acid. Scientific Reports
GAMA, RICARDO RIBEIRO ; ARANTES, LIDIA MARIA REBOLHO BATISTA ; SORROCHE, BRUNA PEREIRA ; DE MARCHI, PEDRO ; MELENDEZ, MATIAS ELISEO ; CARVALHO, RAIANY SANTOS ; DE LIMA, MARCOS ALVES ; VETTORE, ANDRÉ LUIZ ; CARVALHO, ANDRÉ LOPES . Evaluation of acetylation and methylation in oral rinse of patients with head and neck cancer history exposed to valproic acid. Scientific Reports, v. 11, p. 16415, 2021.
TERT promoter mutation C228T increases risk for tumor recurrence and death in head and neck cancer patients
ARANTES LMRB; CRUVINEL-CARLONI, A.; CARVALHO, A. C.; SORROCHE, B. P.; Carvalho, AL; SCAPULATEMPO-NETO, C.; REIS, R. M. TERT promoter mutation C228T increases risk for tumor recurrence and death in head and neck cancer patients. FRONTIERS IN ONCOLOGY, v.10, p.1275, 2020.
Impact of genetic variants in clinical outcome of a cohort of patients with oropharyngeal squamous cell carcinoma
CARVALHO, A. C. ; PERDOMO, S. ; SANTOS, W. ; FERNANDES, G. C. ; JESUS, L. M. ; CARVALHO, R. S. ; SCAPULATEMPO-NETO, C. ; CARAVINA, G. ; SORROCHE, B. P. ; Arantes LMRB ; MELENDEZ, M.E. ; MARCHI, P. R. M. ; HAYES, N. ; REIS, RUI M. ; Carvalho, AL . Impact of genetic variants in clinical outcome of a cohort of patients with oropharyngeal squamous cell carcinoma. Scientific Reports, v. 10, p. 9970, 2020.
Effect of Induction Chemotherapy on Swallowing in Head and Neck Cancer Patients
PORTAS, J. ; CORREIA, D. ; QUEIJA, D. ; Arantes LMRB ; VIANA, L. S. ; Carvalho, AL . Effect of Induction Chemotherapy on Swallowing in Head and Neck Cancer Patients. Asian Pacific Journal of Cancer Prevention, v. 20, p. 91-96, 2019.
Construction and characterization of a new TRAIL soluble form, active at picomolar concentrations
MELENDEZ, M.E. ; SILVA-OLIVEIRA, R. J. ; VICENTE, A. L. ; Arantes LMRB ; DE CARVALHO, A.C. ; EPSTEIN, A. ; REIS, R. M. ; Carvalho, AL . Construction and characterization of a new TRAIL soluble form, active at picomolar concentrations. Oncotarget , v. 9, p. 27233-27241, 2018.
Clinical and Molecular Characterization of Surgically Treated Oropharynx Squamous Cell Carcinoma Samples
DE CARVALHO AC; MELENDEZ ME; DA SILVA SABATO C; PALMERO EI; ARANTES LMRB; SCAPULATEMPO-NETO C; CARVALHO AL. Clinical and Molecular Characterization of Surgically Treated Oropharynx Squamous Cell Carcinoma Samples. PATHOLOGY & ONCOLOGY RESEARCH, v. 11, p. 1-12, 2018.
Microfluidic-Based Genosensor to Detect Human Papillomavirus (HPV16) for Head and Neck Cancer
SOARES AC; SOARES JC; RODRIGUES VC; FOLLMANN HDM; ARANTES LMRB; DE CARVALHO AC; MELENDEZ ME; FREGNANI JHTG; REIS RM; CARVALHO AL; OLIVEIRA ON. Microfluidic-Based Genosensor to Detect Human Papillomavirus (HPV16) for Head and Neck Cancer. ACS Applied Materials & Interfaces, v. 10, p. 36757-36763, 2018.
Serum, plasma and saliva biomarkers for head and neck cancer
ARANTES, LMRB; DE CARVALHO, AC; MELENDEZ, ME; CARVALHO, AL. Serum, plasma and saliva biomarkers for head and neck cancer. Expert review of molecular diagnostics, v. 18, p. 1-28, 2017.
MiR-21 as prognostic biomarker in head and neck squamous cell carcinoma patients undergoing an organ preservation protocol
ARANTES, LMRB; LAUS, AC; MELENDEZ, ME; CARVALHO, AC; SORROCHE, BP; MARCHI, PRM; EVANGELISTA, AF; SCAPULATEMPO-NETO, C; VIANA, LS; Carvalho, AL. MiR-21 as prognostic biomarker in head and neck squamous cell carcinoma patients undergoing an organ preservation protocol. OncoTarget, p. 9911-9921, 2016.
Validation of methylation markers for diagnosis of oral cavity cancer
ARANTES, LMRB; CARVALHO, AC; MELENDEZ, ME; CENTRONE, CC; GOIS-FILHO, JF; TOPORCOV, TN; CALY, DN; TAJARA, EH; GOLONI-BERTOLLO, EM; Carvalho, AL; GENCAPO. Validation of methylation markers for diagnosis of oral cavity cancer. European Journal of Cancer, v. 51, p. 632-641, 2015.
Methylation as a biomarker for head and neck cancer
ARANTES, LMRB; de Carvalho, AC; Melendez, ME; Carvalho, AL; Gonoli-Berttolo, EM. Methylation as a biomarker for head and neck cancer. Oral Oncology. v. 50, p. 587-592, 2014.
Projetos de Pesquisas
Nome do Projeto: Inibidores de checkpoint imunológico: imunofenotipagem e desfecho clínico para predição de resposta no Hospital de Câncer de Barretos
Agência de Fomento: IEP/HCB: EDITAL N.07/2019
Vigência: 2021
Nome do Projeto: Inibidores de checkpoint imunológico: desfecho clínico e biomarcadores para predição de resposta em pacientes com melanoma
Vigência: 2019 - 2022
Nome do Projeto: Identificação de biomarcadores e desenvolvimento de assinatura gênica para a predição de resposta à terapia com inibidores de checkpoint imunológico em pacientes com melanoma avançado
Agência de Fomento: Chamada Nº 16/2023 – Saúde de Precisão - Ministério da Saúde
Vigência: 01/01/2024 a 31/12/2026
Nome do Projeto: Desenvolvimento de score imunopatológico multiparamétrico para predição de resposta à inibidores de checkpoint em pacientes com melanoma
Agência de Fomento: Programa de Auxílio a Pesquisa do Grupo Brasileiro de Melanoma (GBM)
Vigência: 2023-2024
