Grupos de Pesquisas

Oncologia Pré-Clínica

O Grupo de Pesquisa em Oncologia Pré-Clínica foi criado em 2020 e se dedica a pesquisas utilizando métodos experimentais in vitro, usando principalmente modelos celulares. Por se tratar de um grupo multidisciplinar, os integrantes se dedicam a experimentação celular usando screening de novas moléculas com potencial antineoplásico; estudos funcionais de genes associados a resposta terapêutica; estabelecimento de linhagens primárias; Estabelecimento de modelos celulares e resistência a terapias. Busca de biomarcadores de respostas à terapias antineoplásicas.

Publicações Relevantes

2019

Annona coriacea Mart. Fractions Promote Cell Cycle Arrest and Inhibit Autophagic Flux in Human Cervical Cancer Cell Lines

GOMES, IZABELA N. FARIA; SILVA-OLIVEIRA, RENATO J. ; OLIVEIRA SILVA, VIVIANE A. ; ROSA, MARCELA N. ; VITAL, PATRIK S. ; BARBOSA, MARIA CRISTINA S. ; DOS SANTOS, FÁBIO VIEIRA ; JUNQUEIRA, JOÃO GABRIEL M. ; SEVERINO, VANESSA G. P. ; OLIVEIRA, BRUNO G ; ROMÃO, WANDERSON ; REIS, RUI MANUEL ; RIBEIRO, ROSY IARA MACIEL DE AZAMBUJA . Annona coriacea Mart. Fractions Promote Cell Cycle Arrest and Inhibit Autophagic Flux in Human Cervical Cancer Cell Lines. MOLECULES, v. 24, p. 3963, 2019.

2018

Construction and characterization of a new TRAIL soluble form, active at picomolar concentrations

MELENDEZ, MATIAS ELISEO ; SILVA-OLIVEIRA, RENATO JOSÉ ; VICENTE, ANNA LUIZA SILVA ALMEIDA ; ARANTES, LIDIA MARIA REBOLHO BATISTA ; DE CARVALHO, ANA CAROLINA ; EPSTEIN, ALBERTO LUIS ; REIS, RUI MANUEL ; CARVALHO, ANDRÉ LOPES . Construction and characterization of a new TRAIL soluble form, active at picomolar concentrations. Oncotarget, v. 9, p. 27233-27241, 2018.

2018

In-vitro screening of cytotoxic activity of euphol from Euphorbia-tirucalli on a large panel of human cancer-derived cell lines

SILVA, VIVIANE ; ROSA, MARCELA ; TANSINI, ALINE ; OLIVEIRA, RENATO ; MARTINHO, OLGA ; LIMA, JO’O PAULO ; PIANOWSKI, LUIZ ; REIS, RUI . In-vitro screening of cytotoxic activity of euphol from Euphorbia-tirucalli on a large panel of human cancer-derived cell lines. Experimental and Therapeutic Medicine, v. 16, p. 557-566, 2018.

2018

Expression of tyrosine kinase receptor AXL is associated with worse outcome of metastatic renal cell carcinomas treated with sunitinib

ZUCCA, LUÍS EDUARDO ; MORINI MATUSHITA, MARIANA ANDOZIA ; da Silva Oliveira, Renato José ; SCAPULATEMPO-NETO, CRISTOVAM ; DE LIMA, MARCOS ALVES ; RIBEIRO, GUILHERME GOMES ; VIANA, CRISTIANO RIBEIRO ; CÁRCANO, FLAVIO MAVIGNIER ; REIS, RUI MANUEL . Expression of tyrosine kinase receptor AXL is associated with worse outcome of metastatic renal cell carcinomas treated with sunitinib. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, v. 36, p. 11.e13-11.e21, 2018.

2017

HER Family Receptors are Important Theranostic Biomarkers for Cervical Cancer: Blocking Glucose Metabolism Enhances the Therapeutic Effect of HER Inhibitors

MARTINHO, OLGA; SILVA-OLIVEIRA, RENATO; CURY, FERNANDA P.; BARBOSA, ANA MARTINS ; GRANJA, SARA ; EVANGELISTA, ADRIANE FEIJÓ ; MARQUES, FÁBIO ; MIRANDA-GONÇALVES, VERA ; CARDOSO-CARNEIRO, DIANA ; DE PAULA, FLÁVIA E. ; ZANON, MAICON ; SCAPULATEMPO-NETO, CRISTOVAM ; MOREIRA, MARISE A.R. ; BALTAZAR, FÁTIMA ; LONGATTO-FILHO, ADHEMAR ; REIS, RUI MANUEL . HER Family Receptors are Important Theranostic Biomarkers for Cervical Cancer: Blocking Glucose Metabolism Enhances the Therapeutic Effect of HER Inhibitors. Theranostics, v. 7, p. 717-732, 2017.

2017

AKT can modulate the in vitro response of HNSCC cells to irreversible EGFR inhibitors

JOSÉ SILVA-OLIVEIRA, RENATO; MELENDEZ, MATIAS; MARTINHO, OLGA ; ZANON, MAICON F. ; DE SOUZA VIANA, LUCIANO ; LOPES CARVALHO, ANDR? ; RUI MANUEL REIS, AND . AKT can modulate the in vitro response of HNSCC cells to irreversible EGFR inhibitors. Oncotarget, v. 1, p. 1, 2017.

2016

Anti-EGFR therapy: Strategies in head and neck squamous cell carcinoma

OLIVEIRA-SILVA, JOSÉ; DE CARVALHO, ANA-CAROLINA ; DE SOUZA VIANA, LUCIANO ; CARVALHO, ANDRÉ ; REIS, RUI . Anti-EGFR therapy: Strategies in head and neck squamous cell carcinoma. Recent Patent Reviews on Anti-Cancer Drug Discovery, v. 11, p. 1-1, 2016.

2016

Cytotoxicity of allitinib, an irreversible anti-EGFR agent, in a large panel of human cancer-derived cell lines: KRAS mutation status as a predictive biomarker

SILVA-OLIVEIRA, RENATO JOSÉ; SILVA, VIVIANE ALINE OLIVEIRA ; MARTINHO, OLGA ; CRUVINEL-CARLONI, ADRIANA ; MELENDEZ, MATIAS ELISEO ; ROSA, MARCELA NUNES ; DE PAULA, FLÁVIA ESCREMIM ; DE SOUZA VIANA, LUCIANO ; CARVALHO, ANDRÉ LOPES ; REIS, RUI MANUEL . Cytotoxicity of allitinib, an irreversible anti-EGFR agent, in a large panel of human cancer-derived cell lines: KRAS mutation status as a predictive biomarker. Cellular Oncology, v. 1, p. 1-11, 2016.

2016

Anti-EGFR therapy: Strategies in head and neck squamous cell carcinoma

OLIVEIRA-SILVA, JOSÉ; DE CARVALHO, ANA-CAROLINA ; DE SOUZA VIANA, LUCIANO ; CARVALHO, ANDRÉ ; REIS, RUI . Anti-EGFR therapy: Strategies in head and neck squamous cell carcinoma. Recent Patent Reviews on Anti-Cancer Drug Discovery, v. 11, p. 1-1, 2016.

2016

Tapirira guianensis Aubl. Extracts Inhibit Proliferation and Migration of Oral Cancer Cells Lines

SILVA-OLIVEIRA, RENATO; LOPES, GABRIELA ; CAMARGOS, LUIZ ; RIBEIRO, ANA ; SANTOS, FÁBIO ; SEVERINO, RICHELE ; SEVERINO, VANESSA ; TEREZAN, ANA ; THOMÉ, RALPH ; SANTOS, HÉLIO ; REIS, RUI ; RIBEIRO, ROSY . Tapirira guianensis Aubl. Extracts Inhibit Proliferation and Migration of Oral Cancer Cells Lines. International Journal of Molecular Sciences (Online), v. 17, p. 1839, 2016.

Projetos de Pesquisas

Grupos de Pesquisas

Calendário de Eventos

22 a 26 de novembro

NEC

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