Grupos de Pesquisas

Imuno-Oncologia

O grupo de pesquisa em Imuno-Oncologia surgiu em 2019-2020 com o objetivo de estudar o papel da resposta imune dos pacientes com câncer, quando tratados com imunoterapia. O objetivo principal desta tinha de pesquisa é investigar marcadores imunológicos capazes de distinguir pacientes respondedores de não-respondedores à terapia com inibidores de checkpoint imunológico, em pacientes tratados no Hospital de Amor de Barretos. Acreditamos que com a caracterização do sistema imune destes pacientes, possamos guiar a expansão da imunoterapia para nossa população e assim, poderemos desenvolver melhores estratégias para a identificação dos pacientes que se beneficiarão deste tratamento, permitindo o uso racional desta abordagem terapêutica. Esperamos que os resultados obtidos possam ser aplicados na prática clínica da especialidade, permitindo um melhor delineamento do prognóstico, além do desenvolvimento de novos esquemas terapêuticos para o tratamento destes pacientes, de forma a contribuir para melhoras nas taxas de sobrevida e na qualidade de vida.

Membros de Equipe

Pesquisador Principal

Lidia Maria Rebolho Batista Arantes – PhD


http://lattes.cnpq.br/2019308149950531 lirebolho@hotmail.com

Pesquisadores Colaboradores

Alunos

Bruna Pereira Sorroche


Aluna de doutorado

http://lattes.cnpq.br/6362727361627859

Marcelo Augusto Alves Silva Barbosa


Aluno de Iniciação Científica

http://lattes.cnpq.br/0119156690901206 marcelinhoasb@gmail.com

Nathália de Carvalho Rodrigues


Aluna de Mestrado

http://lattes.cnpq.br/8977011113761985 nathaliadecr@gmail.com

Renan de Jesus Teixeira


Aluno de Doutorado

http://lattes.cnpq.br/6731586162750786 renandjt98@gmail.com

Samuel Pratavieira de Oliveira


Bolsista FAPESP Apoio Técnico Nível 3

http://lattes.cnpq.br/2084147482279381 samuelpratavieira@gmail.com

Victor Gabriel Paes


Bolsista FAPESP Apoio Técnico Nível 3

http://lattes.cnpq.br/8286613750799076 victorgpaes23@gmail.com

Alunos Egressos

Publicações Relevantes

2023

PD-L1 tumor expression as a predictive biomarker of immune checkpoint inhibitors response and survival in advanced melanoma patients in Brazil. Diagnostics

SORROCHE, B. P.; TEIXEIRA, R. J.; PEREIRA, C. A. D.; SANTANA, IARA V. V.; VUJNOVIC, L.; VAZQUEZ, V. L.; Arantes LMRB. PD-L1 tumor expression as a predictive biomarker of immune checkpoint inhibitors response and survival in advanced melanoma patients in Brazil. Diagnostics. , v.13, p.1041 – , 2023.
2022

Using machine learning and an electronic tongue for discriminating saliva samples from oral cavity cancer patients and healthy individuals

BRAZ, D. C. ; POPPOLIN-NETO, M. ; SHIMIZU, F. M. ; SA, A. C. ; MELENDEZ, M. E. ; Arantes LMRB ; Carvalho, AL ; REIS, R. M. ; PAULOVICH, F. V. ; OLIVEIRA, OSVALDO NOVAIS . Using machine learning and an electronic tongue for discriminating saliva samples from oral cavity cancer patients and healthy individuals. TALANTA, v. 243, p. 123327, 2022.

2022

Co-expression of TNF receptors 1 and 2 on melanomas facilitates soluble TNF-induced resistance to MAPK pathway inhibitors. Journal of Translational Medicine

SANDER, CINDY A. ; RUSH, ELIZABETH A. ; SHI, JIAN ; ARANTES, LIDIA M. R. B. ; TESI, RAYMOND J. ; ROSS, MARK A. ; CALDERON, MICHAEL J. ; WATKINS, SIMON C. ; KIRKWOOD, JOHN M. ; FERRIS, ROBERT L. ; BUTTERFIELD, LISA H. ; VUJANOVIC, LAZAR . Co-expression of TNF receptors 1 and 2 on melanomas facilitates soluble TNF-induced resistance to MAPK pathway inhibitors. Journal of Translational Medicine, v. 20, p. 331, 2022.

2022

Analysis of Epstein-Barr Virus (EBV) and PD-L1 Expression in Nasopharyngeal Carcinoma Patients in a Non-Endemic Region. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

DIAS, JOSIANE M. ; SANTANA, IARA V. V. ; DA SILVA, VINICIUS D. ; CARVALHO, ANDRÉ L. ; ARANTES, LIDIA M. R. B. . Analysis of Epstein-Barr Virus (EBV) and PD-L1 Expression in Nasopharyngeal Carcinoma Patients in a Non-Endemic Region. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 23, p. 11720, 2022.

2021

DNA Methylation Markers from Negative Surgical Margins Can Predict Recurrence of Oral Squamous Cell Carcinoma. Cancers

SORROCHE, B. P. ; TALUKDAR, F. R. ; LIMA, S. C. S. ; MELENDEZ, M. E. ; CARVALHO, A. C. ; ALMEIDA, G. C. ; MARCHI, P. R. M. ; LOPES, M. ; PINTO, L. F. R. ; Carvalho, AL ; HERCEG, Z. ; Arantes LMRB . DNA Methylation Markers from Negative Surgical Margins Can Predict Recurrence of Oral Squamous Cell Carcinoma. Cancers, v. 13, p. 2915, 2021.

2021

Evaluation of acetylation and methylation in oral rinse of patients with head and neck cancer history exposed to valproic acid. Scientific Reports

GAMA, RICARDO RIBEIRO ; ARANTES, LIDIA MARIA REBOLHO BATISTA ; SORROCHE, BRUNA PEREIRA ; DE MARCHI, PEDRO ; MELENDEZ, MATIAS ELISEO ; CARVALHO, RAIANY SANTOS ; DE LIMA, MARCOS ALVES ; VETTORE, ANDRÉ LUIZ ; CARVALHO, ANDRÉ LOPES . Evaluation of acetylation and methylation in oral rinse of patients with head and neck cancer history exposed to valproic acid. Scientific Reports, v. 11, p. 16415, 2021.

2020

TERT promoter mutation C228T increases risk for tumor recurrence and death in head and neck cancer patients

ARANTES LMRB; CRUVINEL-CARLONI, A.; CARVALHO, A. C.; SORROCHE, B. P.; Carvalho, AL; SCAPULATEMPO-NETO, C.; REIS, R. M. TERT promoter mutation C228T increases risk for tumor recurrence and death in head and neck cancer patients. FRONTIERS IN ONCOLOGY, v.10, p.1275, 2020.

2020

Impact of genetic variants in clinical outcome of a cohort of patients with oropharyngeal squamous cell carcinoma

CARVALHO, A. C. ; PERDOMO, S. ; SANTOS, W. ; FERNANDES, G. C. ; JESUS, L. M. ; CARVALHO, R. S. ; SCAPULATEMPO-NETO, C. ; CARAVINA, G. ; SORROCHE, B. P. ; Arantes LMRB ; MELENDEZ, M.E. ; MARCHI, P. R. M. ; HAYES, N. ; REIS, RUI M. ; Carvalho, AL . Impact of genetic variants in clinical outcome of a cohort of patients with oropharyngeal squamous cell carcinoma. Scientific Reports, v. 10, p. 9970, 2020.

2019

Effect of Induction Chemotherapy on Swallowing in Head and Neck Cancer Patients

PORTAS, J. ; CORREIA, D. ; QUEIJA, D. ; Arantes LMRB ; VIANA, L. S. ; Carvalho, AL . Effect of Induction Chemotherapy on Swallowing in Head and Neck Cancer Patients. Asian Pacific Journal of Cancer Prevention, v. 20, p. 91-96, 2019.

2018

Construction and characterization of a new TRAIL soluble form, active at picomolar concentrations

MELENDEZ, M.E. ; SILVA-OLIVEIRA, R. J. ; VICENTE, A. L. ; Arantes LMRB ; DE CARVALHO, A.C. ; EPSTEIN, A. ; REIS, R. M. ; Carvalho, AL . Construction and characterization of a new TRAIL soluble form, active at picomolar concentrations. Oncotarget , v. 9, p. 27233-27241, 2018.

2018

Clinical and Molecular Characterization of Surgically Treated Oropharynx Squamous Cell Carcinoma Samples

DE CARVALHO AC; MELENDEZ ME; DA SILVA SABATO C; PALMERO EI; ARANTES LMRB; SCAPULATEMPO-NETO C; CARVALHO AL. Clinical and Molecular Characterization of Surgically Treated Oropharynx Squamous Cell Carcinoma Samples. PATHOLOGY & ONCOLOGY RESEARCH, v. 11, p. 1-12, 2018.

2018

Microfluidic-Based Genosensor to Detect Human Papillomavirus (HPV16) for Head and Neck Cancer

SOARES AC; SOARES JC; RODRIGUES VC; FOLLMANN HDM; ARANTES LMRB; DE CARVALHO AC; MELENDEZ ME; FREGNANI JHTG; REIS RM; CARVALHO AL; OLIVEIRA ON. Microfluidic-Based Genosensor to Detect Human Papillomavirus (HPV16) for Head and Neck Cancer. ACS Applied Materials & Interfaces, v. 10, p. 36757-36763, 2018.

2017

Serum, plasma and saliva biomarkers for head and neck cancer

ARANTES, LMRB; DE CARVALHO, AC; MELENDEZ, ME; CARVALHO, AL. Serum, plasma and saliva biomarkers for head and neck cancer. Expert review of molecular diagnostics, v. 18, p. 1-28, 2017.

2016

MiR-21 as prognostic biomarker in head and neck squamous cell carcinoma patients undergoing an organ preservation protocol

ARANTES, LMRB; LAUS, AC; MELENDEZ, ME; CARVALHO, AC; SORROCHE, BP; MARCHI, PRM; EVANGELISTA, AF; SCAPULATEMPO-NETO, C; VIANA, LS; Carvalho, AL. MiR-21 as prognostic biomarker in head and neck squamous cell carcinoma patients undergoing an organ preservation protocol. OncoTarget, p. 9911-9921, 2016.

2015

Validation of methylation markers for diagnosis of oral cavity cancer

ARANTES, LMRB; CARVALHO, AC; MELENDEZ, ME; CENTRONE, CC; GOIS-FILHO, JF; TOPORCOV, TN; CALY, DN; TAJARA, EH; GOLONI-BERTOLLO, EM; Carvalho, AL; GENCAPO. Validation of methylation markers for diagnosis of oral cavity cancer. European Journal of Cancer, v. 51, p. 632-641, 2015.

2014

Methylation as a biomarker for head and neck cancer

ARANTES, LMRB; de Carvalho, AC; Melendez, ME; Carvalho, AL; Gonoli-Berttolo, EM. Methylation as a biomarker for head and neck cancer. Oral Oncology. v. 50, p. 587-592, 2014.

Projetos de Pesquisas

Nome do Projeto: Inibidores de checkpoint imunológico: imunofenotipagem e desfecho clínico para predição de resposta no Hospital de Câncer de Barretos

Agência de Fomento: IEP/HCB: EDITAL N.07/2019

Vigência: 2021

Nome do Projeto: Caracterização imunofenotípica em melanoma e associação com dados demográficos, clínicos e patológicos

Vigência: 2021

Nome do Projeto: Análise retrospectiva da expressão de EBV e PD-L1 em carcinoma de nasofaringe em uma população brasileira

Agência de Fomento: Programa de Auxílio e Incentivo ao Pesquisador (PAIP)

Vigência: 2021

Nome do Projeto: Inibidores de checkpoint imunológico: desfecho clínico e biomarcadores para predição de resposta em pacientes com melanoma

Vigência: 2019 - 2022

Nome do Projeto: Inibidores de checkpoint imunológico: imunofenotipagem e desfecho clínico para predição de resposta no Hospital de Câncer de Barretos

Agência de Fomento: Auxílio à Pesquisa FAPESP - Jovem Pesquisador

Vigência: 01/05/2021 - 30/04/2026

Grupos de Pesquisas