Grupos de Pesquisas
Oncologia Pré-Clínica
O Grupo de Pesquisa em Oncologia Pré-Clínica foi criado em 2020 e se dedica a pesquisas utilizando métodos experimentais in vitro, usando principalmente modelos celulares. Por se tratar de um grupo multidisciplinar, os integrantes se dedicam a experimentação celular usando screening de novas moléculas com potencial antineoplásico; estudos funcionais de genes associados a resposta terapêutica; estabelecimento de linhagens primárias; Estabelecimento de modelos celulares e resistência a terapias. Busca de biomarcadores de respostas à terapias antineoplásicas.
Membros de Equipe
Pesquisador Principal
Pesquisadores Colaboradores
Alunos
Abu-Bakr A. Ariwoola
Aluno de Doutorado
http://lattes.cnpq.br/4014114860449204 adetayo.ariwoola@yahoo.com
Amanda Helena Tejada
Aluna de Mestrado
http://lattes.cnpq.br/7918703070589237 amandahtejada@gmail.com
Giulia Rodrigues Stringhetta
Aluna de Mestrado
http://lattes.cnpq.br/2276126486920573 giuliastringhetta@outlook.com
Izabela Natalia Faria Gomes
Biologista Especialista
http://lattes.cnpq.br/3405695458679544 izabela.faria.tk@hotmail.com
Maria Clara Fonseca Peixoto
Aluna de Mestrado
http://lattes.cnpq.br/5498501766268216 mclarapeixoto26@gmail.com
Pedro Vitor Silva Resende
Residente em Biologia Molecular
http://lattes.cnpq.br/8233070824849408 pedro-v-resende@hotmail.com
Raquel Arantes Megid
Residente em Biologia Molecular
http://lattes.cnpq.br/8542946854781412 raquelmegidd@gmail.comAlunos Egressos
Publicações Relevantes
Comprehensive Molecular Landscape of Cetuximab Resistance in Head and Neck Cancer Cell Lines
GOMES, I. N. F. ; SILVA-OLIVEIRA, RENATO JOSÉ ; Luciane Sussuchi da Silva ; MARTINHO, O. ; LENGERT, A. V. H. ; EVANGELISTA, A. F. ; Letícia Ferro Leal ; SILVA, V. A. O. ; CARVALHO, A. L. ; REIS, R. M. . Comprehensive Molecular Landscape of Cetuximab Resistance in Head and Neck Cancer Cell Lines. Cells
, v. 1, p. 154, 2022.
Efficacy of Combined Use of Everolimus and Second-Generation Pan-EGFR Inhibitors in KRAS Mutant Non-Small Cell Lung Cancer Cell Lines
Silva-Oliveira, Renato José; Gomes, Izabela Natalia Faria ; Da Silva, Luciane Sussuchi ; Lengert, André Van Helvoort ; Laus, Ana Carolina ; Melendez, Matias Eliseo ; Munari, Carla Carolina ; Cury, Fernanda de Paula ; Longato, Giovanna Barbarini ; Reis, Rui Manuel . INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 23, p. 7774, 2022.
Annona coriacea Mart. Fractions Promote Cell Cycle Arrest and Inhibit Autophagic Flux in Human Cervical Cancer Cell Lines
GOMES, IZABELA N. FARIA; SILVA-OLIVEIRA, RENATO J. ; OLIVEIRA SILVA, VIVIANE A. ; ROSA, MARCELA N. ; VITAL, PATRIK S. ; BARBOSA, MARIA CRISTINA S. ; DOS SANTOS, FÁBIO VIEIRA ; JUNQUEIRA, JOÃO GABRIEL M. ; SEVERINO, VANESSA G. P. ; OLIVEIRA, BRUNO G ; ROMÃO, WANDERSON ; REIS, RUI MANUEL ; RIBEIRO, ROSY IARA MACIEL DE AZAMBUJA . Annona coriacea Mart. Fractions Promote Cell Cycle Arrest and Inhibit Autophagic Flux in Human Cervical Cancer Cell Lines. MOLECULES, v. 24, p. 3963, 2019.
Expression of tyrosine kinase receptor AXL is associated with worse outcome of metastatic renal cell carcinomas treated with sunitinib
ZUCCA, LUÍS EDUARDO ; MORINI MATUSHITA, MARIANA ANDOZIA ; da Silva Oliveira, Renato José ; SCAPULATEMPO-NETO, CRISTOVAM ; DE LIMA, MARCOS ALVES ; RIBEIRO, GUILHERME GOMES ; VIANA, CRISTIANO RIBEIRO ; CÁRCANO, FLAVIO MAVIGNIER ; REIS, RUI MANUEL . Expression of tyrosine kinase receptor AXL is associated with worse outcome of metastatic renal cell carcinomas treated with sunitinib. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, v. 36, p. 11.e13-11.e21, 2018.
In-vitro screening of cytotoxic activity of euphol from Euphorbia-tirucalli on a large panel of human cancer-derived cell lines
SILVA, VIVIANE ; ROSA, MARCELA ; TANSINI, ALINE ; OLIVEIRA, RENATO ; MARTINHO, OLGA ; LIMA, JO’O PAULO ; PIANOWSKI, LUIZ ; REIS, RUI . In-vitro screening of cytotoxic activity of euphol from Euphorbia-tirucalli on a large panel of human cancer-derived cell lines. Experimental and Therapeutic Medicine, v. 16, p. 557-566, 2018.
Construction and characterization of a new TRAIL soluble form, active at picomolar concentrations
MELENDEZ, MATIAS ELISEO ; SILVA-OLIVEIRA, RENATO JOSÉ ; VICENTE, ANNA LUIZA SILVA ALMEIDA ; ARANTES, LIDIA MARIA REBOLHO BATISTA ; DE CARVALHO, ANA CAROLINA ; EPSTEIN, ALBERTO LUIS ; REIS, RUI MANUEL ; CARVALHO, ANDRÉ LOPES . Construction and characterization of a new TRAIL soluble form, active at picomolar concentrations. Oncotarget, v. 9, p. 27233-27241, 2018.
AKT can modulate the in vitro response of HNSCC cells to irreversible EGFR inhibitors
JOSÉ SILVA-OLIVEIRA, RENATO; MELENDEZ, MATIAS; MARTINHO, OLGA ; ZANON, MAICON F. ; DE SOUZA VIANA, LUCIANO ; LOPES CARVALHO, ANDR? ; RUI MANUEL REIS, AND . AKT can modulate the in vitro response of HNSCC cells to irreversible EGFR inhibitors. Oncotarget, v. 1, p. 1, 2017.
HER Family Receptors are Important Theranostic Biomarkers for Cervical Cancer: Blocking Glucose Metabolism Enhances the Therapeutic Effect of HER Inhibitors
MARTINHO, OLGA; SILVA-OLIVEIRA, RENATO; CURY, FERNANDA P.; BARBOSA, ANA MARTINS ; GRANJA, SARA ; EVANGELISTA, ADRIANE FEIJÓ ; MARQUES, FÁBIO ; MIRANDA-GONÇALVES, VERA ; CARDOSO-CARNEIRO, DIANA ; DE PAULA, FLÁVIA E. ; ZANON, MAICON ; SCAPULATEMPO-NETO, CRISTOVAM ; MOREIRA, MARISE A.R. ; BALTAZAR, FÁTIMA ; LONGATTO-FILHO, ADHEMAR ; REIS, RUI MANUEL . HER Family Receptors are Important Theranostic Biomarkers for Cervical Cancer: Blocking Glucose Metabolism Enhances the Therapeutic Effect of HER Inhibitors. Theranostics, v. 7, p. 717-732, 2017.
Tapirira guianensis Aubl. Extracts Inhibit Proliferation and Migration of Oral Cancer Cells Lines
SILVA-OLIVEIRA, RENATO; LOPES, GABRIELA ; CAMARGOS, LUIZ ; RIBEIRO, ANA ; SANTOS, FÁBIO ; SEVERINO, RICHELE ; SEVERINO, VANESSA ; TEREZAN, ANA ; THOMÉ, RALPH ; SANTOS, HÉLIO ; REIS, RUI ; RIBEIRO, ROSY . Tapirira guianensis Aubl. Extracts Inhibit Proliferation and Migration of Oral Cancer Cells Lines. International Journal of Molecular Sciences (Online), v. 17, p. 1839, 2016.
Anti-EGFR therapy: Strategies in head and neck squamous cell carcinoma
OLIVEIRA-SILVA, JOSÉ; DE CARVALHO, ANA-CAROLINA ; DE SOUZA VIANA, LUCIANO ; CARVALHO, ANDRÉ ; REIS, RUI . Anti-EGFR therapy: Strategies in head and neck squamous cell carcinoma. Recent Patent Reviews on Anti-Cancer Drug Discovery, v. 11, p. 1-1, 2016.
Cytotoxicity of allitinib, an irreversible anti-EGFR agent, in a large panel of human cancer-derived cell lines: KRAS mutation status as a predictive biomarker
SILVA-OLIVEIRA, RENATO JOSÉ; SILVA, VIVIANE ALINE OLIVEIRA ; MARTINHO, OLGA ; CRUVINEL-CARLONI, ADRIANA ; MELENDEZ, MATIAS ELISEO ; ROSA, MARCELA NUNES ; DE PAULA, FLÁVIA ESCREMIM ; DE SOUZA VIANA, LUCIANO ; CARVALHO, ANDRÉ LOPES ; REIS, RUI MANUEL . Cytotoxicity of allitinib, an irreversible anti-EGFR agent, in a large panel of human cancer-derived cell lines: KRAS mutation status as a predictive biomarker. Cellular Oncology, v. 1, p. 1-11, 2016.
Anti-EGFR therapy: Strategies in head and neck squamous cell carcinoma
OLIVEIRA-SILVA, JOSÉ; DE CARVALHO, ANA-CAROLINA ; DE SOUZA VIANA, LUCIANO ; CARVALHO, ANDRÉ ; REIS, RUI . Anti-EGFR therapy: Strategies in head and neck squamous cell carcinoma. Recent Patent Reviews on Anti-Cancer Drug Discovery, v. 11, p. 1-1, 2016.
Projetos de Pesquisas
Nome do Projeto: KRASgetaway: investigação pré-clínica para controle do oncogene KRAS
Pesquisador Responsável: Renato J. S. Oliveira
Agência de Fomento: FAPESP
Vigência: 2023-2025
