Grupos de Pesquisas

Grupo de pesquisa em Radiobiologia

Nosso grupo foi criado em 2021 e tem como objetivo avaliar a biologia celular e molecular envolvida nas respostas à radiação, buscando desvendar os mecanismos relacionados às respostas clínicas de pacientes submetidos à radioterapia. Além dos ensaios celulares, também temos interesse em avaliar aspectos da comunicação celular que ocorre por meio de vesículas extracelulares durante a radioterapia. Desta forma, esta
linha de pesquisa envolve estudos in vitro e translacionais, conectando a clínica com a pesquisa básica.

Publicações Relevantes

2025

Extracellular vesicles as the common denominator among the 7 Rs of radiobiology: From the cellular level to clinical practice

Oliveira Dias, J., Sampaio Fagundes, I., Bisio, M. C., da Silva Barboza, V., Jacinto, A. A., &
Altei, W. F. (2025). Extracellular vesicles as the common denominator among the 7 Rs of
radiobiology: From the cellular level to clinical practice. Biochimica et Biophysica Acta.
Reviews on cancer, 1880(3), 189315.

2024

EV-miRNAs from breast cancer patients of plasma as potential prognostic biomarkers of disease recurrence

CAUSIN, RHAFAELA LIMA ; POLEZI, MARIANA REGATIERI ; FREITAS, ANA JULIA
AGUIAR DE ; CALFA, STÉPHANIE ; Altei, Wanessa Fernanda ; DIAS, JÚLIA OLIVEIRA ;
LAUS, ANA CAROLINA ; PESSÔA-PEREIRA, DANIELLE ; KOMOTO, TATIANA TAKAHASI
; EVANGELISTA, ADRIANE FEIJÓ ; SOUZA, CRISTIANO DE PÁDUA ; REIS, RUI MANUEL
; MARQUES, MARCIA MARIA CHIQUITELLI . EV-miRNAs from breast cancer patients of
plasma as potential prognostic biomarkers of disease recurrence. HELIYON, v. 10, p.
e33933, 2024.

2024

BIOCHEMISTRY AND BIOPHYSICS REPORTS

CASALI, BRUNA CARLA ; BAPTISTA, MATHEUS PINTOR ; PACHANE, BIANCA CRUZ ;
CORTEZ, ANELISE ABREU ; Altei, Wanessa Fernanda ; SELISTRE-DE-ARAÚJO,
HELOÍSA SOBREIRO . Blockage of αvβ3 integrin in 3D culture of triple-negative breast
cancer and endothelial cells inhibits migration and discourages endothelial-to-mesenchymal
plasticity. BIOCHEMISTRY AND BIOPHYSICS REPORTS, v. 38, p. 101686, 2024.

2022

Radiotherapy for Prostate cancer using HYpofractionation Directed by UltraSound (RAPHYDUS): a Brazilian public health care system study

FAUSTINO, FABIO DE LIMA COSTA ; Altei, Wanessa Fernanda ; CANTON, HELOISA PELISSER ; MORATO, LEONARDO ; DE PAULA, LIVIA LOAMI RUYS JORGE ; SALVADOR, GABRIELA BERNAL ; FONSECA, DIEGO DE SOUZA LIMA ; GONÇALVES, THAIS KAPP ; KUPELIAN, PATRICK A. ; ZAPAROLLI, JOSE CARLOS ; ERCOLIN, LAURA ; MARCONI, DANIEL GROSSI . Radiotherapy for Prostate cancer using HYpofractionation Directed by UltraSound (RAPHYDUS): a Brazilian public health care system study. Practical Radiation Oncology, 2022.

2022

New insights into the discovery of drugs for triple-negative breast cancer metastasis

ALTEI, WF; PACHANE, B. C. ; Souza, C ; MARQUES, M. M. C. . New insights into the discovery of drugs for triple-negative breast cancer metastasis. Expert Opinion on Drug Discovery, v. 18, p. 1-12, 2022.

2022

Comparing Extracellular Vesicles and Cell Membranes as Biocompatible Coatings for Gold Nanorods: Implications for Targeted Theranostics

MARIA PINCELA LINS, PAULA ; RIBOVSKI, LAÍS ; CORSI ANTONIO, LUANA ; Altei, Wanessa F. ; SELISTRE-DE-ARAÚJO, HELOISA S. ; CANCINO-BERNARDI, JULIANA ; ZUCOLOTTO, VALTENCIR . Comparing Extracellular Vesicles and Cell Membranes as Biocompatible Coatings for Gold Nanorods: Implications for Targeted Theranostics. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, v. 176, p. 168-179, 2022.

2022

Effects of αvβ3 Integrin Blockage in Breast Tumor and Endothelial Cells under Hypoxia In Vitro

CASALI, BRUNA C. ; GOZZER, LARISSA T. ; BAPTISTA, MATHEUS P. ; Altei, Wanessa F. ; SELISTRE-DE-ARAÚJO, HELOISA S. . The Effects of αvβ3 Integrin Blockage in Breast Tumor and Endothelial Cells under Hypoxia In Vitro. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 23, p. 1745, 2022.

2022

Concentration- and time-dependence toxicity of graphene oxide (GO) and reduced graphene oxide (rGO) nanosheets upon zebrafish liver cell line

DE SIQUEIRA, PRISCILA RODRIGUES ; DE SOUZA, JAQUELINE PÉROLA ; ESTEVÃO, BIANCA MARTINS ; Altei, Wanessa Fernanda ; LUSTOSA DO CARMO, TALITA LAURIE ; APARECIDO DOS SANTOS, FABRÍCIO ; DE ARAÚJO, HELOÍSA SOBREIRO SELISTRE ; ZUCOLOTTO, VALTECIR ; FERNANDES, MARISA NARCISO . Concentration- and time-dependence toxicity of graphene oxide (GO) and reduced graphene oxide (rGO) nanosheets upon zebrafish liver cell line. AQUATIC TOXICOLOGY, v. 248, p. 106199, 2022.

2022

Small Extracellular Vesicles from Hypoxic Triple-Negative Breast Cancer Cells Induce Oxygen-Dependent Cell Invasion

Pachane, B. C. ; Nunes, Ana C.C. ; Cataldi, T. R. ; Micocci, K. C. ; Moreira , B. C. ; Labate , C. A. ; Araujo, H. S. S. ; Altei, W. F. . . INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 23, p. 12646, 2022

2022

Tumor heterogeneity and the dilemma of antioxidant therapies in cancer

Selistre-de-Araujo, Heloisa  Sobreiro ; Pachane , Bianca Cruz ; Altei, Wanessa Fernanda . Annals of Translational Medicine, v. 10, p. 1, 2022.

2022

Planning Head and Neck radiotherapy in contrast CT: viability for AAA and AcurosXB

Nardi, Paloma Natali ; Beraldo Oliveira , Bruno ; DE Faria  Morato, Leonardo ; Carmello  Guimarães , Lucas Francisco ; Altei, Wanessa Fernanda ; Giglioli , Milena . Revista Brasileira de Física Médica  (ONLINE), v. 16, p. 652, 2022.

2021

Influence of the breast prosthesis volume in dose distribution in radiotherapy planning

FONSECA, P. V. ; SALVIANO, D. ; ERCOLIN, L. ; BUONGOSTO, F. ; BORGES, A. ; MARCELINO, F. A. S. ; CESAR, D. L. ; SILVA, R. M. S. ; MCCLOSKEY, S. A. ; ALTEI, W. F. ; JACINTO, A. A. ; MATTOS, M. D. . Influence of the breast prosthesis volume in dose distribution in radiotherapy planning. Mastology, v. 31, p. 1-5, 2021.

 

Grupos de Pesquisas