Grupos de Pesquisas
Grupo de pesquisa em Radiobiologia
Nosso grupo foi criado em 2021 e tem como objetivo avaliar a biologia celular e molecular envolvida nas respostas à radiação, buscando desvendar os mecanismos relacionados às respostas clínicas de pacientes submetidos à radioterapia. Além dos ensaios celulares, também temos interesse em avaliar aspectos da comunicação celular que ocorre por meio de vesículas extracelulares durante a radioterapia. Desta forma, esta
linha de pesquisa envolve estudos in vitro e translacionais, conectando a clínica com a pesquisa básica.
Membros de Equipe
Pesquisador Principal
Pesquisadores Colaboradores
Gabriel Oliveira Sawakuchi
Pesquisador Colaborador
https://orcid.org/0000-0001-5560-0650 gsawakuchi@mdanderson.org
Heloisa Sobreiro Selistre de Araújo
Pesquisador Colaborador
http://lattes.cnpq.br/4065824911933203 hsaraujo@ufscar.br
Alunos
Gabriela Karam Rebolho
Aluna de Doutorado
http://lattes.cnpq.br/7214267512238677 gabriela.karam@unesp.br
Igor Sampaio Fagundes
Aluno de Mestrado
http://lattes.cnpq.br/6580400698821995 igor.sampaio.fagundes@hotmail.com
Júlia de Oliveira Martinho
Aluna de Mestrado
http://lattes.cnpq.br/0415272192653649 juliademartinho@gmail.com
Julia Oliveira Dias
Aluna de Doutorado
http://lattes.cnpq.br/6800656883027906 julia.odias@yahoo.com.br
Laís Bueno da Silva Murra
Aluna de Mestrado
http://lattes.cnpq.br/4047424497948819 laissbueno@hotmail.com
Leonardo Levy dos Santos
Aluno de Doutorado
http://lattes.cnpq.br/4682794236902523 leonardolevy16@gmail.com
Mariana de Cássia Bisio
Aluna de Doutorado
http://lattes.cnpq.br/5100657466794680 decassiabisio@gmail.comPublicações Relevantes
Extracellular vesicles as the common denominator among the 7 Rs of radiobiology: From the cellular level to clinical practice
Oliveira Dias, J., Sampaio Fagundes, I., Bisio, M. C., da Silva Barboza, V., Jacinto, A. A., &
Altei, W. F. (2025). Extracellular vesicles as the common denominator among the 7 Rs of
radiobiology: From the cellular level to clinical practice. Biochimica et Biophysica Acta.
Reviews on cancer, 1880(3), 189315.
From the linear accelerator to the linear‑quadratic fitting and alternatives.
Dias, J. O., De Camargo, A., Da Silva, D. D., Fagundes, I. S., Da Silva, L. B., Bisio, M., Giglioli, M., Gadia, R., Jacinto, A., Altei, W. Obtaining cell survival curves in radiobiology: From the linear accelerator to the linear‑quadratic fitting and alternatives. World Academy of Sciences Journal, v. 7, n. 4, 2025. https://doi.org/10.3892/wasj.2025.361
EV-miRNAs from breast cancer patients of plasma as potential prognostic biomarkers of disease recurrence
CAUSIN, RHAFAELA LIMA ; POLEZI, MARIANA REGATIERI ; FREITAS, ANA JULIA
AGUIAR DE ; CALFA, STÉPHANIE ; Altei, Wanessa Fernanda ; DIAS, JÚLIA OLIVEIRA ;
LAUS, ANA CAROLINA ; PESSÔA-PEREIRA, DANIELLE ; KOMOTO, TATIANA TAKAHASI
; EVANGELISTA, ADRIANE FEIJÓ ; SOUZA, CRISTIANO DE PÁDUA ; REIS, RUI MANUEL
; MARQUES, MARCIA MARIA CHIQUITELLI . EV-miRNAs from breast cancer patients of
plasma as potential prognostic biomarkers of disease recurrence. HELIYON, v. 10, p.
e33933, 2024.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
CASALI, BRUNA CARLA ; BAPTISTA, MATHEUS PINTOR ; PACHANE, BIANCA CRUZ ;
CORTEZ, ANELISE ABREU ; Altei, Wanessa Fernanda ; SELISTRE-DE-ARAÚJO,
HELOÍSA SOBREIRO . Blockage of αvβ3 integrin in 3D culture of triple-negative breast
cancer and endothelial cells inhibits migration and discourages endothelial-to-mesenchymal
plasticity. BIOCHEMISTRY AND BIOPHYSICS REPORTS, v. 38, p. 101686, 2024.
Radiotherapy for Prostate cancer using HYpofractionation Directed by UltraSound (RAPHYDUS): a Brazilian public health care system study
FAUSTINO, FABIO DE LIMA COSTA ; Altei, Wanessa Fernanda ; CANTON, HELOISA PELISSER ; MORATO, LEONARDO ; DE PAULA, LIVIA LOAMI RUYS JORGE ; SALVADOR, GABRIELA BERNAL ; FONSECA, DIEGO DE SOUZA LIMA ; GONÇALVES, THAIS KAPP ; KUPELIAN, PATRICK A. ; ZAPAROLLI, JOSE CARLOS ; ERCOLIN, LAURA ; MARCONI, DANIEL GROSSI . Radiotherapy for Prostate cancer using HYpofractionation Directed by UltraSound (RAPHYDUS): a Brazilian public health care system study. Practical Radiation Oncology, 2022.
New insights into the discovery of drugs for triple-negative breast cancer metastasis
ALTEI, WF; PACHANE, B. C. ; Souza, C ; MARQUES, M. M. C. . New insights into the discovery of drugs for triple-negative breast cancer metastasis. Expert Opinion on Drug Discovery, v. 18, p. 1-12, 2022.
Comparing Extracellular Vesicles and Cell Membranes as Biocompatible Coatings for Gold Nanorods: Implications for Targeted Theranostics
MARIA PINCELA LINS, PAULA ; RIBOVSKI, LAÍS ; CORSI ANTONIO, LUANA ; Altei, Wanessa F. ; SELISTRE-DE-ARAÚJO, HELOISA S. ; CANCINO-BERNARDI, JULIANA ; ZUCOLOTTO, VALTENCIR . Comparing Extracellular Vesicles and Cell Membranes as Biocompatible Coatings for Gold Nanorods: Implications for Targeted Theranostics. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, v. 176, p. 168-179, 2022.
Effects of αvβ3 Integrin Blockage in Breast Tumor and Endothelial Cells under Hypoxia In Vitro
CASALI, BRUNA C. ; GOZZER, LARISSA T. ; BAPTISTA, MATHEUS P. ; Altei, Wanessa F. ; SELISTRE-DE-ARAÚJO, HELOISA S. . The Effects of αvβ3 Integrin Blockage in Breast Tumor and Endothelial Cells under Hypoxia In Vitro. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 23, p. 1745, 2022.
Concentration- and time-dependence toxicity of graphene oxide (GO) and reduced graphene oxide (rGO) nanosheets upon zebrafish liver cell line
DE SIQUEIRA, PRISCILA RODRIGUES ; DE SOUZA, JAQUELINE PÉROLA ; ESTEVÃO, BIANCA MARTINS ; Altei, Wanessa Fernanda ; LUSTOSA DO CARMO, TALITA LAURIE ; APARECIDO DOS SANTOS, FABRÍCIO ; DE ARAÚJO, HELOÍSA SOBREIRO SELISTRE ; ZUCOLOTTO, VALTECIR ; FERNANDES, MARISA NARCISO . Concentration- and time-dependence toxicity of graphene oxide (GO) and reduced graphene oxide (rGO) nanosheets upon zebrafish liver cell line. AQUATIC TOXICOLOGY, v. 248, p. 106199, 2022.
Small Extracellular Vesicles from Hypoxic Triple-Negative Breast Cancer Cells Induce Oxygen-Dependent Cell Invasion
Pachane, B. C. ; Nunes, Ana C.C. ; Cataldi, T. R. ; Micocci, K. C. ; Moreira , B. C. ; Labate , C. A. ; Araujo, H. S. S. ; Altei, W. F. . . INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 23, p. 12646, 2022
Tumor heterogeneity and the dilemma of antioxidant therapies in cancer
Selistre-de-Araujo, Heloisa Sobreiro ; Pachane , Bianca Cruz ; Altei, Wanessa Fernanda . Annals of Translational Medicine, v. 10, p. 1, 2022.
Planning Head and Neck radiotherapy in contrast CT: viability for AAA and AcurosXB
Nardi, Paloma Natali ; Beraldo Oliveira , Bruno ; DE Faria Morato, Leonardo ; Carmello Guimarães , Lucas Francisco ; Altei, Wanessa Fernanda ; Giglioli , Milena . Revista Brasileira de Física Médica (ONLINE), v. 16, p. 652, 2022.
Influence of the breast prosthesis volume in dose distribution in radiotherapy planning
FONSECA, P. V. ; SALVIANO, D. ; ERCOLIN, L. ; BUONGOSTO, F. ; BORGES, A. ; MARCELINO, F. A. S. ; CESAR, D. L. ; SILVA, R. M. S. ; MCCLOSKEY, S. A. ; ALTEI, W. F. ; JACINTO, A. A. ; MATTOS, M. D. . Influence of the breast prosthesis volume in dose distribution in radiotherapy planning. Mastology, v. 31, p. 1-5, 2021.
