Grupos de Pesquisas
Grupo de pesquisa em Radiobiologia
Nosso grupo foi criado em 2021 e tem como objetivo avaliar a biologia celular e molecular envolvida nas respostas à radiação, buscando desvendar os mecanismos relacionados às respostas clínicas de pacientes submetidos à radioterapia. Além dos ensaios celulares, também temos interesse em avaliar aspectos da comunicação celular que ocorre por meio de vesículas extracelulares durante a radioterapia. Desta forma, esta
linha de pesquisa envolve estudos in vitro e translacionais, conectando a clínica com a pesquisa básica.
Membros de Equipe
Pesquisador Principal
Pesquisadores Colaboradores
Alunos
Gabriela Karam Rebolho
Aluna de Doutorado
http://lattes.cnpq.br/7214267512238677 gabriela.karam@unesp.br
Igor Sampaio Fagundes
Aluno de Mestrado
http://lattes.cnpq.br/6580400698821995 igor.sampaio.fagundes@hotmail.com
Júlia de Oliveira Martinho
Aluna de Mestrado
http://lattes.cnpq.br/0415272192653649 juliademartinho@gmail.com
Julia Oliveira Dias
Aluna de Doutorado
http://lattes.cnpq.br/6800656883027906 julia.odias@yahoo.com.br
Laís Bueno da Silva Murra
Aluna de Mestrado
http://lattes.cnpq.br/4047424497948819 laissbueno@hotmail.com
Mariana de Cássia Bisio
Aluna de Doutorado
http://lattes.cnpq.br/5100657466794680 decassiabisio@gmail.comPublicações Relevantes
Extracellular vesicles as the common denominator among the 7 Rs of radiobiology: From the cellular level to clinical practice
Oliveira Dias, J., Sampaio Fagundes, I., Bisio, M. C., da Silva Barboza, V., Jacinto, A. A., &
Altei, W. F. (2025). Extracellular vesicles as the common denominator among the 7 Rs of
radiobiology: From the cellular level to clinical practice. Biochimica et Biophysica Acta.
Reviews on cancer, 1880(3), 189315.
EV-miRNAs from breast cancer patients of plasma as potential prognostic biomarkers of disease recurrence
CAUSIN, RHAFAELA LIMA ; POLEZI, MARIANA REGATIERI ; FREITAS, ANA JULIA
AGUIAR DE ; CALFA, STÉPHANIE ; Altei, Wanessa Fernanda ; DIAS, JÚLIA OLIVEIRA ;
LAUS, ANA CAROLINA ; PESSÔA-PEREIRA, DANIELLE ; KOMOTO, TATIANA TAKAHASI
; EVANGELISTA, ADRIANE FEIJÓ ; SOUZA, CRISTIANO DE PÁDUA ; REIS, RUI MANUEL
; MARQUES, MARCIA MARIA CHIQUITELLI . EV-miRNAs from breast cancer patients of
plasma as potential prognostic biomarkers of disease recurrence. HELIYON, v. 10, p.
e33933, 2024.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
CASALI, BRUNA CARLA ; BAPTISTA, MATHEUS PINTOR ; PACHANE, BIANCA CRUZ ;
CORTEZ, ANELISE ABREU ; Altei, Wanessa Fernanda ; SELISTRE-DE-ARAÚJO,
HELOÍSA SOBREIRO . Blockage of αvβ3 integrin in 3D culture of triple-negative breast
cancer and endothelial cells inhibits migration and discourages endothelial-to-mesenchymal
plasticity. BIOCHEMISTRY AND BIOPHYSICS REPORTS, v. 38, p. 101686, 2024.
Radiotherapy for Prostate cancer using HYpofractionation Directed by UltraSound (RAPHYDUS): a Brazilian public health care system study
FAUSTINO, FABIO DE LIMA COSTA ; Altei, Wanessa Fernanda ; CANTON, HELOISA PELISSER ; MORATO, LEONARDO ; DE PAULA, LIVIA LOAMI RUYS JORGE ; SALVADOR, GABRIELA BERNAL ; FONSECA, DIEGO DE SOUZA LIMA ; GONÇALVES, THAIS KAPP ; KUPELIAN, PATRICK A. ; ZAPAROLLI, JOSE CARLOS ; ERCOLIN, LAURA ; MARCONI, DANIEL GROSSI . Radiotherapy for Prostate cancer using HYpofractionation Directed by UltraSound (RAPHYDUS): a Brazilian public health care system study. Practical Radiation Oncology, 2022.
New insights into the discovery of drugs for triple-negative breast cancer metastasis
ALTEI, WF; PACHANE, B. C. ; Souza, C ; MARQUES, M. M. C. . New insights into the discovery of drugs for triple-negative breast cancer metastasis. Expert Opinion on Drug Discovery, v. 18, p. 1-12, 2022.
Comparing Extracellular Vesicles and Cell Membranes as Biocompatible Coatings for Gold Nanorods: Implications for Targeted Theranostics
MARIA PINCELA LINS, PAULA ; RIBOVSKI, LAÍS ; CORSI ANTONIO, LUANA ; Altei, Wanessa F. ; SELISTRE-DE-ARAÚJO, HELOISA S. ; CANCINO-BERNARDI, JULIANA ; ZUCOLOTTO, VALTENCIR . Comparing Extracellular Vesicles and Cell Membranes as Biocompatible Coatings for Gold Nanorods: Implications for Targeted Theranostics. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, v. 176, p. 168-179, 2022.
Effects of αvβ3 Integrin Blockage in Breast Tumor and Endothelial Cells under Hypoxia In Vitro
CASALI, BRUNA C. ; GOZZER, LARISSA T. ; BAPTISTA, MATHEUS P. ; Altei, Wanessa F. ; SELISTRE-DE-ARAÚJO, HELOISA S. . The Effects of αvβ3 Integrin Blockage in Breast Tumor and Endothelial Cells under Hypoxia In Vitro. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 23, p. 1745, 2022.
Concentration- and time-dependence toxicity of graphene oxide (GO) and reduced graphene oxide (rGO) nanosheets upon zebrafish liver cell line
DE SIQUEIRA, PRISCILA RODRIGUES ; DE SOUZA, JAQUELINE PÉROLA ; ESTEVÃO, BIANCA MARTINS ; Altei, Wanessa Fernanda ; LUSTOSA DO CARMO, TALITA LAURIE ; APARECIDO DOS SANTOS, FABRÍCIO ; DE ARAÚJO, HELOÍSA SOBREIRO SELISTRE ; ZUCOLOTTO, VALTECIR ; FERNANDES, MARISA NARCISO . Concentration- and time-dependence toxicity of graphene oxide (GO) and reduced graphene oxide (rGO) nanosheets upon zebrafish liver cell line. AQUATIC TOXICOLOGY, v. 248, p. 106199, 2022.
Small Extracellular Vesicles from Hypoxic Triple-Negative Breast Cancer Cells Induce Oxygen-Dependent Cell Invasion
Pachane, B. C. ; Nunes, Ana C.C. ; Cataldi, T. R. ; Micocci, K. C. ; Moreira , B. C. ; Labate , C. A. ; Araujo, H. S. S. ; Altei, W. F. . . INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 23, p. 12646, 2022
Tumor heterogeneity and the dilemma of antioxidant therapies in cancer
Selistre-de-Araujo, Heloisa Sobreiro ; Pachane , Bianca Cruz ; Altei, Wanessa Fernanda . Annals of Translational Medicine, v. 10, p. 1, 2022.
Planning Head and Neck radiotherapy in contrast CT: viability for AAA and AcurosXB
Nardi, Paloma Natali ; Beraldo Oliveira , Bruno ; DE Faria Morato, Leonardo ; Carmello Guimarães , Lucas Francisco ; Altei, Wanessa Fernanda ; Giglioli , Milena . Revista Brasileira de Física Médica (ONLINE), v. 16, p. 652, 2022.
Influence of the breast prosthesis volume in dose distribution in radiotherapy planning
FONSECA, P. V. ; SALVIANO, D. ; ERCOLIN, L. ; BUONGOSTO, F. ; BORGES, A. ; MARCELINO, F. A. S. ; CESAR, D. L. ; SILVA, R. M. S. ; MCCLOSKEY, S. A. ; ALTEI, W. F. ; JACINTO, A. A. ; MATTOS, M. D. . Influence of the breast prosthesis volume in dose distribution in radiotherapy planning. Mastology, v. 31, p. 1-5, 2021.
